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US 7,803,790 B2Granted
Compounds for modulating TRPV3 function
AssigneeHydra Biosciences, Inc.
InventorsJayhong A. Chong, Christopher Fanger, Glenn R. Larsen, William C. Lumma, Jr., Anu Mahadevan, Peter Meltzer, Magdalene M. Moran, Amy Ripka, Dennis John Underwood, Manfred Weigele, Xiaoguang Zhen
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Abstract
The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
Claims10
A method for treating, reducing the frequency of, or delaying the onset of pain, comprising administering to a patient in need thereof an effective amount of a compound of formula Va or a salt thereof:
- wherein
- R1 is absent or represents one or more substituents on the ring to which they are attached wherein each of said one or more substituents are, independently for each occurrence, selected from among lower alkyl, alkoxy, carboxyl, amido, sulfonamido, heterocyclyl, cycloalkyl, hydroxyl, amino, acylamino, sulfonylamino, or R1 taken together with the carbon to which it is attached forms a carbonyl or thiocarbonyl, and R2 and R3 are absent or represent one or more substituents on the ring to which they are attached, wherein each of said one or more substituents are, independently for each occurrence, selected from among lower alkyl, alkoxy, carboxyl, amido, sulfonamido, heterocyclyl, cycloalkyl, hydroxyl, amino, acylamino, sulfonylamino, nitro, halogen, CF3, or cyano.
Dependencies are inferred from the claim text.