Vitamin D analog—RAK, methods and uses thereof
AssigneeWisconsin Alumni Research Foundation
InventorsHector F. Deluca, Grazia Chiellini, Pawel Grzywacz, Lori A. Plum, Margaret Clagett-Dame
Life of this patent
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Abstract
Compounds of formula IA or IB are provided where X1, X2 and X3 are independently selected from H or hydroxy protecting groups and R1 is selected from straight or branched chain alkyl groups having from 1 to 8 carbon atoms; straight or branched chain alkenyl groups having from 2 to 8 carbon atoms; straight or branched chain hydroxy-substituted alkyl groups having from 1 to 8 carbon atoms; straight and branched chain hydroxy-substituted alkenyl groups having from 2 to 8 carbon atoms. Such compounds are used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.
Claims20
A compound having the formula IA or IB
- wherein X1, X2 and X3 are independently selected from H and hydroxy protecting groups;
- and R1 is selected from straight or branched chain alkyl groups having from 1 to 8 carbon atoms;
- straight or branched chain alkenyl groups having from 2 to 8 carbon atoms;
- straight or branched chain hydroxy-substituted alkyl groups having from 1 to 8 carbon atoms;
- straight and branched chain hydroxy-substituted alkenyl groups having from 2 to 8 carbon atoms.
The compound having the formula IIA
The compound having the formula IIB
Dependencies are inferred from the claim text.