Modulation of growth hormone receptor expression and insulin-like growth factor expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsKenneth W Dobie, Ravi Jain
Life of this patent
Estimating the term…
Abstract
Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.
Claims33
A compound consisting of 20 to 50 nucleobases, wherein said compound comprises the nucleobase sequence of SEQ ID NO:
- 19;
- and wherein said compound is at least 90% complementary to SEQ ID NO:
- 4 as measured over the entire length of said compound.
A compound comprising a modified oligonucleotide consisting of 20 linked nucleosides and having a nucleobase sequence consisting of the nucleobase sequence recited in SEQ ID NO:
- 19, wherein said modified oligonucleotide consists of a ten deoxynucleotide region flanked on both the 5′ end and the 3′ end of said ten deoxynucleotide region with five 2′-O-(2-methoxyethyl) nucleotides, wherein each internucleoside linkage in said modified oligonucleotide is a phosphorothioate linkage and each cytosine in said modified oligonucleotide is a 5-methylcytosine.
Dependencies are inferred from the claim text.