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AssigneeInstitut fur Medizintechnologie Magdeburg (IMTM) GmbH
InventorsSiegfried Ansorge, Uwe Lendeckel, Klaus Neubert, Dirk Reinhold, Robert Vetter, Harald Gollnick
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Provided are combinations of inhibitors of dipeptidyl peptidase IV (DP IV) and of enzymes having the same substrate specificity (DP IV-analogous enzymatic activity) and inhibitors of alanyl aminopeptidase (aminopeptidase N, APN) and of enzymes having the same substrate specificity (APN-analogous enzymatic activity) and use of the same to obtain a more than additive to superadditive inhibition for the treatment of arteriosclerosis, for the treatment of allergic reactions of the type I according to the Gell and Coombs classification and for the treatment of dermatological diseases with follicular and epidermal hyperkeratoses and an enhanced proliferation of keratinocytes.
A method for producing in an individual in need of treatment for allergic reactions of type I a more than additive to superadditive inhibition of the activation, proliferation, and DNA-synthesis and production of TH2 cytokines by, human T lymphocytes and mononuclear cells, comprising administering to the individual an effective amount of a composition comprising an inhibitor of dipeptidyl peptidase IV (DP IV) as well as of enzymes having the same substrate specificity (DP IV-analogous enzymatic activity) in combination with an inhibitor of alanyl-aminopeptidase (aminopeptidase N, APN) as well as of enzymes having the same substrate specificity (APN-analogous enzymatic activity).
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