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US 7,803,775 B2Granted
Protein kinase C peptides for use in withdrawal
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsDaria Mochly-Rosen, Joan J. Kendig, Sarah M. Sweitzer
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Abstract
A method for managing withdrawal from an addictive substance is described. The method involves administering one or more peptides having specific activity for the ε and/or γ isozyme of protein kinase C (PKC). The peptide(s) can be administered prior to, concurrent with, or subsequent to administration of the addictive substance. Also described is a kit having at least one container containing a peptide having isozyme-specific activity for εPKC or γPKC and instructions for use.
Claims6
A kit comprising,
- i) at least one container containing a peptide having isozyme-specific inhibitory activity for γPKC, wherein said peptide consists of a sequence selected from the group consisting of SEQ ID NO:2 and SEQ ID NOs:4-14;
- and
- (ii) instructions for use.
A kit comprising,
- i) at least one container containing a peptide having isozyme-specific inhibitory activity for γPKC;
- and
- (ii) instructions for use;
- wherein said peptide is formulated for intracellular delivery by conjugation to a carrier peptide.
1 more element
Dependencies are inferred from the claim text.