I kappa B kinase complex as a target for the treatment of Huntington's disease
AssigneeCalifornia Institute of Technology
InventorsAli Khoshnan, Paul H. Patterson
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Abstract
The present invention provides methods and compositions for protecting cells from the toxicity of mutant huntingtin (Htt) protein and for treatment of Huntington's disease (HD). The methods generally involve administering to cells or a patient an effective amount of an IKK inhibitor. In addition, methods are provided for identifying therapeutics for the treatment of HD.
Claims12
A method for protecting cells comprising mutant Htt from the toxicity of mutant Htt, comprising inhibiting I-κB kinase (IKK) activity in said cells by contacting said cells with an IKK inhibitor, wherein said inhibitor inhibits the activation of NF-κB dependent pathways.
Dependencies are inferred from the claim text.