Antimicrobial peptides derived from CAP18
AssigneesOctoplus Technologies B.V., Academisch Ziekenhuis Leiden
InventorsJohannes Jakobus Grote, Jan Wouter Drijfhout, Pieter Sicco Hiemstra, Marcel Jan Vonk, Maartje Johanna Nell, Guido Vincent Bloemberg
Life of this patent
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Abstract
The invention provides methods to exert antimicrobial effects in prophylactic or therapeutic treatment of bacterial or fungal infections employing polypeptides that have affinity to microbial and fungal toxins.
Claims30
A pharmaceutical composition for treating a bacterial or fungal infection in a mammal that comprises the compound of formula (1) that comprises a core amino acid sequence:
- X1KEFX2RIVX3RIKX4FLRX5LVX6 (SEQ ID NO:
- 1), wherein
- X1 represents an N-terminal part;
- X2 is K or E;
- X3 is Q or E;
- X4 is D or R;
- X5 is N or E;
- X6 represents a C-terminal part;
- wherein one or more of the amino acids of the core amino acid sequence is optionally derivatized, and wherein
- (a) the N-terminal part is acetylated, and/or
- (b) the C-terminal part is amidated, and/or
- (c) the core amino acid sequence is different from KEFKRIVQRIKDFLRNLV (SEQ ID NO:2),
- along with one or more pharmaceutically acceptable carriers or excipients.
A method to exert an antimicrobial effect in the prophylactic or therapeutic treatment of a bacterial or fungal infection of a mammal, which method comprises administering to a mammal in need of such treatment an effective amount of a compound of formula (1) that comprises a core amino acid sequence:
- X1KEFX2RIVX3RIKX4FLRX5LVX6 (SEQ ID NO:1), wherein
- X1 represents an N-terminal part;
- X2 is K or E;
- X3 is Q or E;
- X4 is D or R;
- X5 is N or E;
- X6 represents a C-terminal part;
- wherein one or more of the amino acids of the core amino acid sequence is optionally derivatized, and wherein
- (a) the N-terminal part is acetylated, and/or
- (b) the C-terminal part is amidated, and/or
- (c) the core amino acid sequence is different from KEFKRIVQRIKDFLRNLV (SEQ ID NO:2).
Dependencies are inferred from the claim text.