US 7,803,754 B2 · Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level

Abstract

The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject over that provided by the amount of the GPR119 agonist or the amount of the DPP-IV inhibitor alone and the use of such a combination for treating or preventing diabetes and conditions related thereto or conditions ameliorated by increasing a blood GLP-1 level. The present invention also relates to the use of a G protein-coupled receptor to screen for GLP-1 secretagogues.

Claims24

Dependent claims

A method of identifying a GLP-1 secretagogue, comprising:

(a) administering a GPR119 agonist to a mammal;
and
(b) determining a GLP-1 level in a blood or plasma sample obtained from the mammal,
wherein the ability of the GPR119 agonist to increase a GLP-1 level in the mammal is indicative of the agonist being a GLP-1 secretagogue.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

11/603,417Filed 22 Nov 2006 · continuation

Priority

10 Jan 2005

Published

US 2007/0072804 A129 Mar 2007

Granted

28 Sep 2010

Term ends

Not estimatedThe source records don’t support an estimate.

Classification38 codes

G01N 33/76
Involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and…:…
A61K 31/00
Medicinal preparations containing organic active ingredients
A61K 31/401
Having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil: proline; Derivatives…
A61K 31/415
Having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole: 1,2-Diazoles

Family

Application60/643,086Us provisional application · filed 10 Jan 2005

Application60/683,172Us provisional application · filed 19 May 2005

Application60/726,880Us provisional application · filed 14 Oct 2005

Application11/328,405Parent of this continuation · filed 9 Jan 2006

US 2007/0072804 A1Pre-grant publication · published 29 Mar 2007

US 2006/0154866 A1Published application

US 7,803,754 B2This patent

From the US filing history. Foreign family members aren’t listed.

Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level

Life of this patent

Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level

Life of this patent

Abstract

Claims24