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US 7,803,576 B2Granted
Nucleic acid sequences encoding VEGF-like factors and uses thereof
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsYuichi Hirata, Junichi Nezu
Life of this patent
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Abstract
The invention relates to VEGF-like nucleic acid sequences, their use, and vectors and transformants containing such sequences.
Claims6
An isolated DNA encoding a protein shown by SEQ ID NO:
- 1.
An isolated DNA that is capable of hybridizing with the complement of the DNA shown by SEQ ID NO:
- 2 under the conditions of hybridizing under a temperature gradient of 68° C. to 55° C. for 2 hours and washing with a 2×SSC solution containing 0.05% SDS at room temperature for 10 minute for four times and with a 0.1×SSC solution containing 0.1% SDS at 45° C. for 3 minutes and encodes a protein having at least one activity selected from the group consisting of:
- vascular formation, lymphatic vessel formation, pathological neovascularization, increasing vascular permeability, edema formation, wound healing, and promoting collateral vessel formation.
An isolated DNA having 90% or higher sequence homology to the DNA shown by SEQ ID NO:
- 2 and encoding a protein having at least one activity selected from the group consisting of:
- vascular formation, lymphatic vessel formation, pathological neovascularization, increasing vascular permeability, edema formation, wound healing, and promoting collateral vessel formation.
Dependencies are inferred from the claim text.