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US 7,803,572 B2Granted
Protease detection assay
AssigneeAtlas Genetics Limited
InventorsHelen Braven, Russell Keay, Stephen Flower
Life of this patent
Estimating the term…
Abstract
The invention provides methods and compounds for detecting protease activity in a sample solution comprising contacting the sample solution with a protease substrate labelled with an electrochemically active marker, providing conditions under which any protease which may be present in the sample may degrade the protease substrate and electrochemically determining information relating to the electrochemically active marker.
Claims12
A method for detecting protease activity in a sample solution comprising the steps of:
- i) contacting the sample solution with a protease substrate labeled with an electrochemically active marker, wherein the electrochemically active marker is a metallocene moiety,
- ii) providing conditions under which a protease present in the sample solution may degrade the protease substrate, wherein the protease is capable of recognizing the protease substrate, and
- iii) electrochemically determining information relating to the electrochemically active marker, thereby detecting the protease activity in the sample.
Dependencies are inferred from the claim text.