Marburg I mutant of factor VII activating protease (FSAP) as risk factor for arterial thrombosis and methods of detecting FSAP and FSAP mutations

A method of detecting atherothrombosis risk in an individual, comprising:

• obtaining one or more body fluids from said individual;
• determining Factor VII Activating Protease (FSAP) protein concentration in said one or more body fluids of the individual;
• and
• determining whether there is a reduced FSAP protein concentration in one or more of the body fluids compared to the FSAP protein concentration in a standard sample;
• wherein, atherothrombosis risk in the individual is indicated by an FSAP protein concentration that is reduced compared to the FSAP protein concentration in the standard sample.