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US 7,803,568 B2Granted
Carbodithioate ligands for nanotechnology and biosensing applications
AssigneePurdue Research Foundation
InventorsAlexander Wei, Yan Zhao
Life of this patent
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Abstract
The present invention is directed to methods and products related to carbodithioate ligands bonded to surfaces. The invention is further directed to molecular and biomolecular sensing methods based on analyte recognition by carbodithioate ligands bonded to surfaces.
Claims8
A method for preparing a surface for use as a biosensor, comprising:
- forming a carbodithioate ligand by mixing CS2 with a nucleophile represented by formula NHR1R2 in the presence of a solvent selected from the group consisting of methanol, ethanol, n-propyl alcohol, isopropyl alcohol, water, toluene, dichloromethane, dichlorobenzene and combination thereof and
- immersing the surface in the mixture to cause the carbodithioate ligand to bond thereto, the surface being selected from at least one of a Group 13 metal, a Group 14 metal, a Group 15 metal, iron oxide, cadmium selenide, cadmium sulfide, indium tin oxide and gold;
- wherein the formed carbodithioate ligand is represented by the structure R1R2N—CS2;
- wherein R1 and R2 are independently selected from —H, alkyl, acyl, aryl, heteroaryl, —OR3, —NR4R5, SiR6R7R8 or SR9;
- R3, R4, R5, R6, R7, and R8 are independently selected from —H, alkyl, acyl, aryl, or heteroaryl;
- and
- R9 is aryl or heteroaryl.
4 more elements
A method for preparing a surface for use as a biosensor, comprising:
- forming a carbodithioate ligand by mixing CS2 with a nucleophile in the presence of a suitable solvent, the nucleophile being selected from the group consisting of dimethylamine, diethylamine, diisopropylamine, dibutylamine, didecylamine, dipicolylamine, diethanolamine, di(hexaethyleneglycol)amine, morpholine, pyridine, praline, oligopeptides bearing N-terminal prolines, piperazinyl terpyridine, nortriptylene, methamphetamine, reductive amination products of oligosaccharides with primary amines, biotin hydrazide, hexamethyldisilazane, and oligo(ethyleneglycol)diamines conjugated to molecular recognition elements such as folic acid or pteroic acid;
- and
- immersing the surface in the mixture to cause the carbodithioate ligand to bond thereto, the surface being selected from the group consisting of a Group 13 metal, a Group 14 metal, a Group 15 metal, iron oxide, cadmium selenide, cadmium sulfide, indium tin oxide and gold;
- wherein said solvent is selected from the group consisting of methanol, ethanol, n-propyl alcohol, isopropyl alcohol, water, toluene, dichloromethane, dichlorobenzene and combination thereof.
1 more element
Dependencies are inferred from the claim text.