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US 7,803,558 B2Granted
Modulation of aqueous humor outflow by targeting vascular-endothelial-cadherin in Schlemm's canal cells
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsW Daniel Stamer, Ronald L Heimark
Life of this patent
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Abstract
The present invention provides methods of inhibiting cadherins between Schlemm's canal cells, to a patient suffering from glaucoma as well as screening for substances that inhibit cadherins between the Schlemm's canal cells.
Claims8
A method for screening for a substance that inhibits VE-cadherin protein adhesion to between Schlemm's canal cells, the method comprising
- culturing Schlemm's canal cells on a plate comprising all of the extracellular domain of VE-cadherin in the presence of the substance;
- and measuring the adhesion of the Schlemm's canal cells to the VE-cadherin on the plate, wherein a reduction in adhesion compared to adhesion in the absence of the substance is indicative that the substance inhibits adhesion between VE-cadherin and Schlemm's canal cells.
Dependencies are inferred from the claim text.