Methods and compositions for use in the treatment of filovirus mediated disease conditions
AssigneeThe J. David Gladstone Institutes
InventorsMark A. Goldsmith, Stephen Chan
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Abstract
Methods and compositions are provided for at least slowing the progression of a filovirus mediated disease condition in a host. In the subject methods, an effective amount of an agent that at least reduces the amount of folate receptor mediated filovirus cell entry is administered to the host. The subject methods find use in both the prevention and treatment of filovirus associated disease conditions, including Marburg and Ebola-Zaire virus mediated disease conditions.
Claims12
A method for identifying a candidate agent for reducing the incidence of binding of filovirus to a folate receptor, or reducing the incidence of internalization of filovirus into a permissive cell the treatment of a filovirus associated disease condition, said method comprising:
- a) contacting a folate receptor with a filovirus or a folate receptor-binding fragment of a filovirus envelope glycoprotein and a test compound;
- and
- b) determining the effect of said test compound on the binding interaction between said folate receptor and said folate receptor-binding fragment of a filovirus envelope glycoprotein or said filovirus;
- wherein a test compound that reduces the binding interaction between said folate receptor and said folate receptor-binding fragment of a filovirus envelope glycoprotein or said filovirus, compared to the binding interaction in the absence of the test compound, is a candidate agent for reducing the incidence of binding of filovirus to a folate receptor, or reducing the incidence of internalization of filovirus into a permissive cell.
Dependencies are inferred from the claim text.