Method for detecting Alzheimer's disease
AssigneeAventis Pharma S.A.
InventorsSandrine Mace, Sylvain Ricard, Emmanuelle Cousin, Laurent Pradier, Jésus Benavides, Jean-François Deleuze
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Abstract
The present invention relates to a method for diagnosing an individual for early onset Alzheimer's disease by measuring the presence or absence of the minor allele of the rs908832 polymorphism of the ABCA2 gene. The presence of the minor allele of the rs908832 polymorphism of the ABCA2 gene indicates that the individual may be suffering from Alzheimer's disease or exhibits an increased risk of developing Alzheimer's disease.
Claims7
A method for determining whether a Caucasian individual may have an increased risk of early development of Alzheimer's disease, comprising the steps of:
- i. obtaining a biological sample of the Caucasian individual that contains DNA from the Caucasian individual;
- and
- ii. determining whether the DNA of the biological sample contains a minor allele rs908832 polymorphism of the ABCA2 gene in which an adenine is located at position 348 of SEQ ID NO:1, or a thymidine is located at position 201 of SEQ ID NO:3 wherein the presence the minor allele rs908832 polymorphism of the ABCA2 gene indicates the Caucasian individual may have an increased risk of early development of Alzheimer's disease.
Dependencies are inferred from the claim text.