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US 7,803,537 B2Granted
Parallel genotyping of multiple patient samples
AssigneeIllumina, Inc.
InventorsJian-Bing Fan, Mark S Chee
Life of this patent
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Abstract
The present invention relates to parallel genotyping (or other sample analysis) of multiple patients by direct sample immobilization onto microspheres of an array. The patient beads can then be used in a variety of target analyte analyses.
Claims15
An array composition comprising:
- a) a substrate with a surface;
- and
- b) a population of microspheres comprising at least a first and a second microsphere,
- wherein said first microsphere comprises a plurality of 10 to 10,000 different target analytes from a first individual, and
- wherein said first microsphere further comprises a first identifier binding ligand that identifies said plurality of different target analytes from said first individual,
- wherein said second microsphere comprises a plurality of 10 to 10,000 different target analytes from a second individual, and
- wherein said second microsphere further comprises a second, different identifier binding ligand that identifies said plurality of different target analytes from said second individual;
- wherein said population of microspheres are attached to about 1,000 to 1,000,000,000 discrete sites per cm2 on said surface.
5 more elements
Dependencies are inferred from the claim text.