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US 7,803,531 B2Granted
Method of inducing apoptosis by reducing the level of thiamin
AssigneeBrandeis University
InventorsChandler Fulton, Elaine Y. Lai
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Abstract
The disclosure describes methods for inducing apoptosis of a selected group of vertebrate cells in vivo by reducing the level of thiamin in the cells. Included are methods for inducing apoptosis of cancer cells. Also described are compounds and compositions for use in methods of thiamin depletion and treating diseases such as cancer, and methods for identifying thiamin-depleting agents and for preparing pharmaceutical compositions.
Claims22
A method of inducing apoptosis of a selected group of vertebrate cells in vivo, comprising reducing the level of thiamin in said cells,
- wherein said reducing comprises administering to an organism having said selected group of vertebrate cells at least one thiamin-depleting agent,
- wherein said thiamin-depleting agent is targeted to said selected group of vertebrate cells,
- wherein said thiamin-depleting agent is selected from the group consisting of a thiamin antimetabolite, a thiamin-cleaving compound, and a recombinant gene that encodes a polypeptide that acts as a thiamin-depleting agent, and
- wherein said thiamin antimetabolite is selected from the group consisting of a pyrithiamin, a thiamin substituted at the C-4 position of the thiamin pyrimidine, oxythiamin, an amprolium, and derivatives thereof.
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Dependencies are inferred from the claim text.