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US 7,803,527 B2Granted
Inactivated bovine herpes virus-1 and methods
AssigneeNovartis AG
InventorJohn Mateland Herbert
Life of this patent
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Abstract
This invention related to a method of immunizing cattle to reduce the effects of infection by bovine herpes virus 1, including abortion and stillbirth, by administering inactivated bovine herpes virus 1 prior to breeding.
Claims20
A method for immunizing cattle, the method comprising:
- administering to the cattle, within about 6 months prior to breeding, a composition that includes inactivated bovine herpesvirus-1 (BHV-1) and an adjuvant, wherein the cattle that become pregnant and become exposed to BHV-1 subsequent to the administering, have a reduced rate of abortions or stillbirths as compared to cattle that have not been administered the composition and become exposed to BHV-1 during or immediately prior to pregnancy.
A method for protecting a bovine fetus against reproductive effects of BHV-1, the method comprising:
- administering an oil-adjuvanted, inactivated BHV-1 vaccine composition to cows or heifers within 6 months prior to pregnancy, to increase serum titers of antibodies specific for BHV-1 and to provide protection against the reproductive effects of BHV-1 in cows or heifers that become pregnant, wherein protection against the reproductive effects of BHV-1 means that vaccinated cows or heifers have a lower rate of abortion or stillbirth of the fetus than do unvaccinated cows or heifers.
A method for reducing, in cattle, rate of abortions associated with BHV-1, the method comprising:
- providing to female cattle, prior to pregnancy, two administrations of a composition that includes inactivated BHV-1, BVD1, BVD2, PI3, BRSV, and an oil-based emulsion adjuvant, wherein the first administration occurs within one year of breeding the cattle and the second administration occurs within 6 months of breeding the cattle, and wherein cattle that become pregnant as a result of the breeding have a reduced rate of abortions associated with BHV-1 than do control cattle that have not been provided with the administrations of the composition.
Dependencies are inferred from the claim text.