Polycationic peptide coatings and methods of coating implantable medical devices
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorsStephen D. Pacetti, Eugene T. Michal, Syed F. A. Hossainy, Ni Ding, Wouter E. Roorda
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Abstract
Methods of forming coatings comprising a polycationic peptide for medical devices are disclosed. Also disclosed is a coating comprising a polycationic peptide.
Claims19
A method of coating an implantable medical device comprising:
- (a) incorporating a polycationic peptide into polymeric microspheres or beads;
- (b) adding the microspheres or beads to a composition comprising a polymer;
- and
- (c) applying the composition to a medical device,
- wherein the microspheres or beads are obtained by suspension polymerization of monomers.
A method of coating an implantable medical device comprising:
- (a) incorporating a polycationic peptide into polymeric microspheres or beads;
- (b) adding the microspheres or beads to a composition comprising a polymer;
- and
- (c) applying the composition to a medical device,
- wherein the microspheres or beads are obtained by emulsion copolymerization of at least one neutral monomer, at least one anionic monomer, at least one cross-linking monomer, or a combination thereof.
A method of coating an implantable medical device comprising:
- (a) incorporating a polycationic peptide into polymeric microspheres or beads;
- (b) adding the microspheres or beads to a composition comprising a polymer;
- and
- (c) applying the composition to a medical device,
- wherein the polycationic peptide comprises heptaarginine.
A coating for an implantable medical device, wherein the coating is UV-curable and comprises a hydrogel polymer and a polycationic peptide incorporated into the hydrogel polymer, wherein the polycationic peptide comprises heptaarginine.
Dependencies are inferred from the claim text.