Artificial low-density lipoprotein carriers for transport of substances across the blood-brain barrier
AssigneeBlanchette Rockefeller Neurosciences Institute
InventorsThomas J. Nelson, Daniel L. Alkon, Alessandro Quattrone
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Abstract
This invention relates to a highly efficient artificial low-density lipoprotein (LDL) carrier system for the targeted delivery therapeutic agents across the blood-brain barrier (BBB). In particular, this invention relates to artificial LDL particles comprised of three lipid elements: phosphatidyl choline, fatty-acyl-cholesterol esters, and at least one apolipoprotein. The present invention further relates to compositions, methods and kits comprising artificial LDL particles for targeting drugs to and across the BBB for the prevention and treatment of brain diseases.
Claims44
An artificial low density lipoprotein (LDL) particle comprising an outer phospholipid monolayer and a solid lipid core, wherein the outer phospholipid monolayer comprises at least one cloned apolipoprotein and the solid lipid core contains at least one therapeutic agent selected from the group consisting of bryologs, macrocyclic lactones, isoprenoids, 7-substituted indolactam V derivatives, napthalenesulfonamides, lineolic acid derivatives, diacylglycerol kinase inhibitors, growth factors, or growth factor activators, wherein the at least one cloned apolipoprotein is apolipoprotein E.
Dependencies are inferred from the claim text.