Polycationic peptide hydrogel coatings for cardiovascular therapy
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorSyed F. A. Hossainy
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Abstract
Coatings for implantable medical devices and methods for fabricating the same are disclosed. The coating includes a hydrogel including polycationic peptides, for example the R7.
Claims14
A coating for an implantable medical device, the coating comprising two regions, a first region comprising a hydrogel comprising a polycationic peptide and a second region free from the polycationic peptide;
- wherein the hydrogel further comprises at least one substance selected from the group consisting of polyalginate, sulfonated dextran, poly(dimethylaminoethyl methacrylate), and poly(acrylic acid);
- and
- wherein the peptide comprises a polyarginine having between about 5 and 1,000 repeating units.
A coating for an implantable medical device, the coating comprising two regions, a first region comprising a hydrogel comprising a polycationic peptide and at least one substance selected from the group consisting of polyalginate, sulfonated dextran, poly(dimethylaminoethyl methacrylate), and poly(acrylic acid), and a second region free from the polycationic peptide;
- wherein the polycationic peptide comprises poly(L-arginine), poly(D-arginine), poly(D,L-arginine), poly(L-lysine), poly(D-lysine), poly(δ-guanidino-α-aminobutyric acid), or a mixture of poly(L-arginine) and poly(D-arginine), and
- wherein the poly(L-arginine), poly(D-arginine), poly(D,L-arginine), and the mixture of poly(L-arginine) and poly(D-arginine) independently have between about 5 and 1,000 repeating units.
A coating for a medical device, the coating comprising two regions, a first region comprising a hydrogel comprising a peptide and a second region free from the peptide;
- wherein the peptide comprises a polyarginine having between about 5 and 1,000 repeating units;
- and
- wherein the hydrogel is fabricated from poly(glutamic acid) and the peptide comprising the polyarginine, and the ratio of the peptide comprising the polyarginine to poly(glutamic acid) is from about 1:1 to 5:1.
Dependencies are inferred from the claim text.