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US 7,803,389 B2Granted
Toxoplasma gondii mutant with enhanced homologous recombination and uses thereof
AssigneeTrustees of Dartmouth College
InventorsDavid J. Bzik, Barbara A. Fox
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Abstract
The present invention relates to a mutant Toxoplasma gondii which exhibits enhanced homologous recombination. The mutant of the present invention is a knockout in the KU80-dependent nonhomologous end-joining pathway which finds application in generating T. gondii gene knockouts and gene replacements for use in vaccine and drug development.
Claims15
An isolated mutant Toxoplasma gondii that exhibits enhanced homologous recombination resulting from knockout mutation of the locus encoding KU80 protein of SEQ ID NO:2.
Dependencies are inferred from the claim text.