Method of treatment comprising administration of a cytokine antagonist molecule
AssigneeAres Trading S.A.
InventorsRichard Joseph Fagan, Andrew Robert Davids, Christopher Benjamin Phelps, Christine Power, Ursula Boschert, Yolande Chvatchko
Life of this patent
Estimating the term…
Abstract
This invention relates to novel uses of a protein sequence (INSP052EC), herein identified as an immunoglobulin domain-containing cell surface recognition, in the diagnosis, prevention and treatment of diseases, in particular those related to the excessive expression and/or secretion of cytokines.
Claims8
A method of treating acute liver disease or inflammatory skin disease comprising administering to an individual having acute liver disease or inflammatory skin disease a composition comprising a pharmaceutically acceptable carrier and a polypeptide, said polypeptide:
- a) consisting of SEQ ID NO:22;
- b) consisting of SEQ ID NO:20;
- c) comprising SEQ ID NO:29;
- or
- d) comprising SEQ ID NO:30.
A method of decreasing TNF-α levels or IL-6 levels in an individual comprising the administration of a composition comprising a pharmaceutically acceptable carrier and a polypeptide, said composition being administered in an amount that reduces TNF-α levels or IL-6 levels in said individual and said polypeptide:
- a) comprising SEQ ID NO:
- 20;
- b) comprising SEQ ID NO:
- 29;
- c) comprising SEQ ID NO:
- 30;
- or
- d) comprising SEQ ID NO:
- 22;
- and
- wherein said TNF-α or IL-6 levels are determined to be reduced.
A method of decreasing TNF-α levels or IL-6 levels in an individual comprising the administration of a composition comprising a pharmaceutically acceptable carrier and a polypeptide, said composition being administered in an amount that reduces TNF-α levels or IL-6 levels in said individual and said polypeptide:
- a) consisting of SEQ ID NO:
- 20;
- b) consisting of SEQ ID NO:
- 27;
- c) consisting of SEQ ID NO:
- 28;
- d) consisting of SEQ ID NO:
- 29;
- e) consisting of SEQ ID NO:
- 30;
- or
- f) consisting of SEQ ID NO:
- 22.
Dependencies are inferred from the claim text.