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AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsVivian Takafuji, Xin Wei Wang
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Based on the observation of the cooperation of osteopontin (OPN) and matrixmetalloproteinase-9 (MMP-9) in the promotion of the metastatic phenotype, therapies and diagnostic assays are disclosed for the treatment of a tumor that overexpresses OPN, such as hepatocellular carcinoma (HCC), for example metastatic HCC. In one example, methods of treating a tumor include administration of an agent that reduces cellular invasion resulting from the interaction between a fragment of OPN (OPN-5kD) generated by MMP-9 cleavage and CD44 receptor. Examples of such agents include fragments of OPN-5kD and antibodies specific for OPN-5kD. Therapeutic compositions are also provided that include such agents. Also provided are methods of diagnosing or prognosing a tumor, for example by detecting expression of OPN-5kD peptide or OPN-c mRNA in a biological sample obtained from the subject. Also provided are antibodies that specifically bind OPN-5kD.
A method for reducing the growth an OPN-expressing tumor cell, comprising contacting the cell with a therapeutically effective amount of a composition comprising one or more peptides consisting of the amino acid sequence of SEQ ID NO:
A composition comprising one or more peptides consisting of the amino acid sequence of SEQ ID NO:
A method for reducing growth of an OPN-expressing hepatocellular carcinoma (HCC) in a mammal, comprising:
A method for reducing the invasiveness of an OPN-expressing hepatocellular carcinoma (HCC) metastasis in a mammal, comprising:
A method for reducing the invasiveness of an OPN-expressing cancer in a mammal, comprising:
A method for reducing growth a tumor comprising OPN-expressing tumor cells in a mammal, comprising administering to the mammal a therapeutically effective amount of a composition comprising one or more peptides consisting of the amino acid sequence of SEQ ID NO:
Dependencies are inferred from the claim text.