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US 7,803,371 B2Granted
Anti-VEGF antibody
AssigneeEpitomics, Inc.
InventorsYaohuang Ke, Weimin Zhu, Guo-Liang Yu
Life of this patent
Estimating the term…
Abstract
An antibody is provided. In certain cases, the antibody comprises: a) a heavy chain variable domain that comprises CDR regions that are substantially identical to the heavy chain CDR regions of a selected antibody and b) a light chain variable domain that comprises CDR regions that are substantially identical to the light chain CDR regions of the selected antibody, where the antibody binds a selected target.
Claims13
A monoclonal antibody comprising:
- a) an antibody variable domain comprising:
- i. a heavy chain variable domain comprising:
- a CDR1 region identical to amino acid residues 30-35 of SEQ ID NO:
- 4, a CDR2 region identical to amino acid residues 50-66 of SEQ ID NO:
- 4 and a CDR3 region identical to amino acid residues 98-109 of SEQ ID NO:
- 4;
- and
- ii. a light chain variable domain comprising:
- a CDR1 region identical to amino acid residues 23-35 of SEQ ID NO:
- 43, a CDR2 region identical to amino acid residues 51-57 of SEQ ID NO:
- 43 and a CDR3 region identical to amino acid residues 90-101 of SEQ ID NO:
- 43;
- or
- b) a variant of said antibody variable domain that is otherwise identical to said antibody variable domain except for up to 8 amino acid substitutions in said CDR regions;
- wherein the antibody binds human VEGF.
12 more elements
Dependencies are inferred from the claim text.