Attenuated Francisella bacteria
AssigneeBoard of Regents, The University of Texas System
InventorsKarl E. Klose, Bernard P. Arulanandam
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Abstract
In one embodiment, there is disclosed a method of inducing an immune response in a subject comprising administering to the subject a Francisella bacterium that includes an alteration in the nucleic acid sequence encoding the mglA, iglA, iglB, iglC, or iglD gene of the bacterium.
Claims12
A method for producing an attenuated Francisella bacterium comprising introducing an alteration in the nucleic acid sequence of the iglD gene of the bacterium.
A composition comprising an attenuated Francisella bacterium with a genome that comprises an alteration in the nucleic acid sequence of the iglD gene of the bacterium.
Dependencies are inferred from the claim text.