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US 7,803,362 B2Granted
Glycosylated interferon alpha
AssigneesSynageva BioPharma Corp., University of GA Research Foundation
InventorsRobert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
Life of this patent
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Abstract
The invention relates to interferon-α molecules having certain O-linked oligosaccharide structures.
Claims10
A composition comprising an interferon-α molecule glycosylated with:
- Gal-NAcGal-,
- wherein
- Gal=Galactose, and
- NAcGal=N-Acetyl-Galactosamine.
1 more element
A composition comprising an interferon-α molecule glycosylated with:
- Gal-Gal-NAcGal-,
- wherein
- Gal=Galactose, and
- NAcGal=N-Acetyl-Galactosamine,
- wherein the glycosylation is O-linked at Thr-106.
2 more elements
A composition comprising an interferon-α molecule glycosylated with:
- Gal-Gal-NAcGal-,
- wherein
- Gal=Galactose, and
- NAcGal=N-Acetyl-Galactosamine,
- wherein the interferon-α is human interferon-α.
2 more elements
A composition comprising an interferon-α molecule glycosylated with:
- Gal-Gal-NAcGal-,
- wherein
- Gal=Galactose, and
- NAcGal=N-Acetyl-Galactosamine,
- wherein the interferon-α is pegylated.
2 more elements
Dependencies are inferred from the claim text.