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US 7,803,351 B2Granted
Blood brain barrier permeation peptides
AssigneeWashington University
InventorsVijay Sharma, David Piwnica-Worms
Life of this patent
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Abstract
Novel blood-brain barrier permeant amyloid-targeting peptides and peptide conjugates are described. The peptide conjugates include a radioisotope or other label in a stable complex that translocates across brain capillary endothelial cell monolayers. The labeled peptide conjugate binds to amyloid plaques (Aβ) associated with Alzheimer's disease, and is useful for the targeted delivery of therapeutic and diagnostic molecules into the brain.
Claims12
A compound comprising:
- a blood brain barrier (BBB)-permeant, Aβ-targeting peptide comprising an amino acid sequence of SEQ ID NO:
- 1;
- and
- a chelation core;
- wherein the Aβ-targeting peptide is coupled to the chelation core.
2 more elements
Dependencies are inferred from the claim text.