Medical device with coating that promotes endothelial cell adherence
AssigneeOrbusNeich Medical, Inc.
InventorsMichael John Bradley Kutryk, Robert John Cottone, Jr., Stephen Maxwell Rowland
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Abstract
A medical device with a coating for capturing target cells in vivo is provided. In particular, the medical device is coated with at least one layer of matrix and a layer of antibodies, antibody fragments or combinations thereof, which bind with specificity to mature or progenitor endothelial cells at various developmental stages to form an endothelial cell layer on the surface of the device. The coated medical device can be, for example, a stent or a synthetic graft and is useful in therapy of diseases such as restenosis, atherosclerosis, and thromboembolic complications.
Claims13
An implantable medical device comprising a lumen and a luminal surface, said luminal surface comprising a coating comprising one or more layers of a matrix and a therapeutically effective amount of single type of antibody, antibody fragments or combinations thereof attached to said one or more layers of said matrix, said single type of antibody, antibody fragments or combinations thereof being compatible to binding selectively a specific cell surface antigen of circulating autologous endothelial progenitor cells in peripheral blood and capturing the endothelial progenitor cells on the luminal surface of the device in vivo, wherein said coating stimulates adherence and proliferation of said endothelial progenitor cells on the luminal surface of said medical device to rapidly form a confluent endothelium in situ.
A tubular expandable stent having a lumen and a luminal surface, said luminal surface comprising a coating comprising one or more layers of a matrix and a therapeutically effective amount of single type of antibody, antibody fragments or combinations thereof covalently attached to said one or more layers of said matrix, said single type of antibody, antibody fragments or combinations thereof being capable of binding to a specific cell surface antigen, CD34, of circulating peripheral endothelial progenitor cells on the luminal surface of the stent in vivo, wherein said coating stimulates adherence and proliferation of said endothelial progenitor cells to form an endothelium in situ after implantation.
Dependencies are inferred from the claim text.