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US 7,799,937 B2Granted
Metal coordinated compositions
AssigneeSynthonics, Inc.
InventorThomas Piccariello
Life of this patent
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Abstract
A metal coordination complex of a biologically active moiety and a metal is disclosed. The complex confers to the biologically active moiety an improved performance which can include potency, stability, absorbability, targeted delivery, and combinations thereof.
Claims10
A metal coordination complex, comprising:
- a biologically active moiety;
- and
- a metal atom;
- wherein the biologically active moiety comprises a first functional group having a heteroatom and second functional group having a heteroatom;
- wherein the first functional group and the second functional group are capable of forming a metal coordination bond;
- wherein the first functional group and the second functional group are in a spatial relationship such that the first functional group and the second functional group are capable of participating in the formation of a stable chelate with the metal atom;
- wherein the biologically active moiety comprises triiodothyronine, the first functional group comprises nitrogen, and the second functional group comprises oxygen;
- and
- wherein the metal atom comprises zinc.
6 more elements
A metal coordination complex, comprising:
- a biologically active moiety;
- and
- a metal atom;
- wherein the biologically active moiety comprises a first protonated heteroatom and a second protonated heteroatom;
- wherein the biologically active moiety has a pKa of approximately equal to water or lower than water;
- wherein the first protonated heteroatom and the second protonated heteroatom are in a spatial relationship such that the first protonated heteroatom and the second protonated heteroatom are capable of participating in the formation of a stable chelate with the metal atom;
- wherein the biologically active moiety comprises triiodothyronine, the first protonated heteroatom comprises nitrogen, and the second protonated heteroatom comprises oxygen;
- and
- wherein the metal atom comprises zinc.
6 more elements
Dependencies are inferred from the claim text.