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AssigneePioneer Surgical Orthobiologics, Inc.
InventorsFrancis V. Lamberti, Richard Chris Klann, Ronald Stewart Hill
Estimating the term…
The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffolds for implantable medical devices, and casting or binding materials suitable for the construction of medical devices. The intrinsic bioactivity of the hydrogel matrix makes it useful as a gel or paste in multiple applications, including as a cell attachment scaffold that promotes wound healing around an implanted device, as gels and pastes for induction of localized vasculogenesis, wound healing, tissue repair, and regeneration, as a wound adhesive, and for tissue bulking.
A cross-linked bioactive hydrogel matrix comprising a polyglycan covalently cross-linked to a tissue-derived or synthetic polypeptide, and further comprising at least one enhancing agent selected from the group consisting of polar amino acids, divalent cation chelators, and combinations thereof;
A cross-linked bioactive hydrogel matrix comprising dextran or oxidized dextran covalently cross-linked to gelatin, and further comprising at least one enhancing agent selected from the group consisting of polar amino acids, divalent cation chelators, and combinations thereof;
A cross-linked bioactive hydrogel matrix comprising a polyglycan covalently cross-linked to a tissue-derived or synthetic polypeptide and further comprising one or more divalent cation chelators;
A cross-linked bioactive hydrogel matrix comprising a polyglycan covalently cross-linked to a tissue-derived or synthetic polypeptide, and further comprising one or more polar amino acids;
A cross-linked bioactive hydrogel matrix comprising a polyglycan covalently cross-linked to a polypeptide, and further comprising at least one enhancing agent selected from the group consisting of polar amino acids, divalent cation chelators, and combinations thereof;
Dependencies are inferred from the claim text.