Interleukin-18 binding proteins, their preparation and use
AssigneeYeda Research and Development Co. Ltd.
InventorsDaniela Novick, Charles Dinarello, Menachem Rubinstein, Soo Hyun Kim
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Abstract
Interleukin-18 binding proteins which are capable of binding IL-18 and/or modulating and/or blocking IL-18 activity are provided. Methods for their isolation and recombinant production, DNAs encoding them, DNA vectors expressing them, vecotors useful for their expression in humans and other mammals, antibodies against them are also provided.
Claims36
An isolated nucleic acid encoding the polypeptide of SEQ. ID. NO. 4, 6 or 8.
An isolated nucleic acid comprising a nucleotide sequence encoding a polypeptide which has at least 95% sequence identity to SEQ ID. NO. 2 or 6 and binds IL-18.
An isolated nucleic acid molecule which hybridizes under stringent condition to the entire nucleic acid sequence of SEQ 1, 3, 5, or 7.
An isolated nucleic acid encoding a polypeptide of SEQ. ID. NO. 2, 4, 6 or 8 except wherein said polypeptide does not have a leader sequence.
An isolated nucleic acid molecule comprising a nucleotide sequence encoding a IL-18 binding protein (IL-18BP) wherein said IL-18BP comprises the amino acid sequence of SEQ ID NO:10 and is selected from the group consisting of
- (a) a polypeptide comprising the amino acid sequence of SEQ ID NO:2 or 6;
- (b) a polypeptide as defined in (a) without a leader sequence;
- (c) a mutein of the polypeptide defined in (a) or (b), characterized in that the mutein has at least 95% sequence identity to SEQ ID NO:
- 2 or 6, and binds IL-18.
Dependencies are inferred from the claim text.