A method of administering an agent into an intravascular line port, comprising:
- providing a port access device comprising:
- a first component having a chamber comprising an agent to be administered into an intravascular line port;
- a second component comprising a cleaning agent;
- and
- a third component comprising a microbiocidal agent reversibly attached to the first component;
- removing the second component from the device;
- contacting external surfaces of the port with the second cleaning agent;
- injecting the agent to be administered from the chamber into the port;
- removing the third component from the device;
- and
- capping the port with the third component.