US 7,794,710 B2Granted

Methods of enhancing T cell responsiveness

AssigneeMayo Foundation for Medical Education and Research

InventorsLieping Chen, Scott E. Strome

Life of this patent

Estimating the term…

Abstract

The invention features methods of enhancing the responsiveness of a T cell. Such methods involve interfering with the interaction between a T cell and a B7-H1 molecule.

Claims20

Dependent claims

A method of inhibiting tumor cell proliferation in a subject, comprising:

(a) identifying a subject with cancer;
and
(b) administering to the subject an antibody that binds to B7-H1.

Dependencies are inferred from the claim text.

Facts

Application: 10/127,282Filed 22 Apr 2002 · us provisional application
Priority: 20 Apr 2001
Published: US 2003/0039653 A127 Feb 2003
Granted: 14 Sep 2010
Term ends: Not estimatedThe source records don’t support an estimate.

Classification20 codes

C07K 16/2827
Against the immunoglobulin superfamily: against B7 molecules, e.g. CD80, CD86
A61K 40/11
Characterised by the cell type used: t-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer…
A61K 40/32
Characterised by the recombinant expression of specific molecules in the cells of the immune system: t-cell receptors [TCR]
A61K 40/42
Vertebrate antigens: cancer antigens

Family

Application60/285,137Us provisional application · filed 20 Apr 2001
US 2003/0039653 A1Pre-grant publication · published 27 Feb 2003
US 7,794,710 B2This patent

From the US filing history. Foreign family members aren’t listed.

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