Immunizing compositions encoding an epitope obtained from the HIV-1 capsid protein cyclophilin A binding site
OwnerNelson M. Karpinventor
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Abstract
The present invention relates to an immunogenic composition. More particularly, the present invention is a composition directed to eliciting an immune response to at least one binding site of Cyclophilin A on the HIV capsid protein. (SEQ ID NOS: 2, 4, and 6) The present invention contemplates three categories of embodiments: protein or protein fragments (SEQ ID NOS: 2, 4, and 6), messenger RNA, or DNA/RNA. DNA/RNA compositions (SEQ ID NOS 1, 3, 5, 7, 9, and 11) may be either naked or recombinant. The present invention further contemplates use with a variety of immune stimulants.
Claims34
An immunizing composition comprising, a nucleic acid encoding an HIV-1 capsid protein cyclophilin A (CypA) binding site selected from the group consisting of SEQ ID NOS:
- 1, 3, and 5 and a nucleic acid encoding a pharmaceutically acceptable carrier wherein said composition is capable of eliciting a Th-1 immune response to HIV-1.
A method of eliciting an immune response in an animal, which comprises administering an immunizing composition comprising, a nucleic acid encoding an HIV-1 capsid protein cyclophilin A (CypA) binding site consisting of SEQ ID NOS:
- 1, 3, and 5;
- and a nucleic acid encoding a pharmaceutically acceptable carrier wherein said composition is capable of eliciting a Th-1 immune response to HIV-1.
An immunizing composition comprising, a nucleic acid encoding an HIV-1 capsid protein cyclophilin A (CypA) binding site selected from the group comprising SEQ ID NOS:
- 1, 3, and 5;
- a nucleic acid encoding an adjuvant comprising cobra venom factor;
- and a nucleic acid encoding a pharmaceutically acceptable carrier, wherein said composition is capable of inducing an HIV-1 specific Th-1 immune response.
Dependencies are inferred from the claim text.