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US 7,785,806 B2Granted
Method for determining the immunogenicity of an antigen
AssigneeVaxdesign Corporation
InventorsWilliam L. Warren, Donald Drake, III, Janice Moser, Inderpal Singh, Haifeng Song, Eric Mishkin
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Abstract
The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.
Claims2
A method for determining the immunogenicity of an antigen in vitro comprising:
- preparing a cell culture comprising dendritic cells primed with an antigen;
- adding syngeneic B cells to the cell culture;
- adding allogeneic T cells to the cell culture;
- and
- measuring a B cell response to said antigen and comparing the measured B cell response to a B cell response in a control culture in which said antigen was not utilized, thereby determining the immunogenicity of an antigen in vitro.
2 more elements
Dependencies are inferred from the claim text.