Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
AssigneeIncept, LLC
InventorAmarpreet S. Sawhney
Life of this patent
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Abstract
Pharmaceutically acceptable hydrogel polymers of natural, recombinant or synthetic origin, or hybrids thereof, are introduced in a dry, less hydrated, or substantially deswollen state and rehydrate in a physiological environment to undergo a volumetric expansion and to affect sealing, plugging, or augmentation of tissue, defects in tissue, or of organs. The hydrogel polymers may deliver therapeutic entities by controlled release at the site. Methods to form useful devices from such polymers, and to implant the devices are provided.
Claims14
A method of preventing bleeding via a percutaneous puncture site comprising:
- providing a hydrogel article in a substantially deswollen state preformed as a rolled sheet;
- deploying the hydrogel article into the percutaneous puncture site;
- and
- allowing the hydrogel article to hydrate and expand within the puncture site to prevent bleeding via the percutaneous puncture site.
A method for closure of a percutaneous puncture site, comprising:
- positioning a sheath through a puncture wound to provide access to an artery;
- removing the sheath from the puncture wound after completing a procedure;
- introducing a bioabsorbable, freeze dried hydrogel comprising a preformed rolled sheet into the puncture wound via a tubular device;
- exposing the hydrogel to fluids within the puncture wound, the hydrogel hydrating and expanding within the puncture wound to seal the puncture wound.
Dependencies are inferred from the claim text.