Compositions and methods for the treatment and prevention of disease

A method for the treatment of malaria comprising:

• administering to an individual in need thereof, a therapeutic composition comprising an effective amount of a compound of the formula B:
• wherein R1, R2, R3, R4, and R5 represent, each independent from the other, a member selected from the group consisting of:
• a hydrogen atom;
• an amino acid side chain;
• a (C1-C10) alkyl;
• (C1-C10) alkenyl;
• (C1-C10) alkynyl;
• (C5-C12) monocyclic or bicyclic aryl;
• (C5-C14) monocyclic or bicyclic aralkyl;
• monocyclic or bicyclic (C5-C14) heteroaralkyl;
• and (C1-C10) monocyclic or bicyclic heteroaryl group having up to 5 heteroatoms selected from N, O, S, and P said groups being able to be non-substituted or substituted by 1 to 6 substituents further selected from the group consisting of:
• a halogen atom, an NO2, OH, amidine, benzamidine, imidazole, 1,2,3-triazole, alkoxy, (C1-C4), amino, piperazine, piperidine, dialkylamino, guanidine group, bis alkylated or bis acylated guanido group, carboxylic acid, carboxamide, ester, hydroxamic acid, phosphinic acid, phosphonate, phosphonamidate, sulfhydryl and any combination thereof;
• or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier or excipient.