Triazole derivative or salt thereof

A compound represented by the formula (I) or a salt thereof:

• [Chem 14]
• wherein the symbols have the following meanings:
• R1:
• —N(R0)S(O)2-lower alkyl, —N(R0)-optionally substituted lower alkyl, —X—R4, or each optionally substituted cycloalkyl or heterocyclic group;
• R4:
• each optionally substituted aryl, cycloalkyl or heterocyclic group;
• X:
• —O—, —N(R5)—, —C(O)—, —S—, —S(O)—, —S(O)2—, —C(O)N(R0)—, —N(R0)C(O)—, —N(R0)C(O)N(R0)—, —N(R6)S(O)2—, —S(O)2N(R6)—, —C(O)-lower alkylene, lower alkylene-C(O)—, —N(R5)-lower alkylene, lower alkylene-N(R5)—, or each optionally substituted lower alkylene, lower alkenylene or lower alkynylene;
• R5:
• —H, lower alkyl, lower alkylene-CO2R0, lower alkylene-OR0, —C(O)R0 or —C(O)-aryl, —S(O)2R0, —S(O)2-aryl or aryl;
• R6:
• —H, lower alkyl, —C(O)R0 or —C(O)-aryl;
• R0:
• the same or different from each other, —H or lower alkyl;
• R2:
• —R7;
• R3:
• —R7, —OR7, —NHR7, —N(R7)S(O)2-lower alkyl, —N(R7)2 or —S-lower alkylene-(optionally substituted aryl);
• or R2 and R3 are combined together with the nitrogen atom and the carbon atom to which they are attached to form a nitrogen-containing heterocycle;
• provided that a ring formed by condensing the triazole ring with the nitrogen-containing heterocycle, which is formed by combining R2 and R3 together with the nitrogen atom and the carbon atom to which they are attached, is not pyrazolo[5,1-c][1,2,4]triazole nor [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine;
• R7:
• the same or different from each other, each optionally substituted lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, aryl or heterocyclic group;
• A and B:
• the same or different from each other, halogen, —R7, —OH, —OR7, —NH2, —NHR7, —N(R7)2, —SR7, —S(O)R7 or —S(O)2R7;
• or A and B may be combined together with the carbon atom to which they are attached to form each optionally substituted cycloalkyl ring or non-aromatic heterocycle;
• provided that:
• 1-(1-{5-[(4-chlorobenzyl)sulfanyl]-4-methyl-4H-1,2,4-triazol-3-yl}-1-methylethyl)-1H-1,2,4-triazole,
• 1-{1-methyl-1-[5-(4-methylphenyl)-4-phenyl-4H-1,2,4-triazol-3-yl]ethyl}-1H-1,2,3-benzotriazole,
• N-[2-(4-chlorophenyl)ethyl]N-methyl-1-(5-methyl-4-phenyl-4H-1,2,4-triazol-3-yl)cyclohex-2-en-1-amine,
• 3-(2,4-dichlorophenyl)-4-methyl-5-[1-(2-thienyl)cyclopropyl]-4H-1,2,4-triazole,
• 3-chloro-4-{4-methyl-5-[1-(2-thienyl)cyclopropyl]-4H-1,2,4-triazol-3-yl}benzamide, and
• N-(3 -chloro-4- {4-methyl-5-[1-(2-thienyl)cyclopropyl]-4H-1,2,4-triazol-3-y1}phenyl)acetamide are excluded.