Radiation therapy methods
AssigneeUniversity of Southern California
InventorsKathleen E. Rodgers, Gere diZerega
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Abstract
The present invention provides methods and kits for mitigating radiation induced tissue damage, improving the effectiveness of radiation therapy, to support bone marrow transplantation, and promoting megakaryocyte production and mobilization and platelet production, each method comprising the administration of an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists.
Claims36
An improved method of pluripotent stem cell transplantation, the improvement comprising administering to a subject in need of pluripotent stem cell transplantation in amount effective of a peptide comprising SEQ ID NO:4 to improve one or more of white blood cell survival, white blood cell number, subject survival, and platelet number in the subject after bone marrow transplantation, wherein the administering occurs either before, simultaneously with, or after pluripotent stem cell transplantation.
Dependencies are inferred from the claim text.