Pharmaceutical compositions based on anticholinergics and additional active ingredients
AssigneeBoehringer Ingelheim Pharma GmbH & Co. KG
InventorsMichel Pairet, Michael P. Pieper, Christopher John Montague Meade, Richard Reichl, Christel Schmelzer, Birgit Jung
Life of this patent
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Abstract
A pharmaceutical composition comprising an anticholinergic and at least one additional active ingredient selected from among corticosteroids, dopamine agonistes, PDE-IV inhibitors, NK1-antagonists, endothelin antagonists, antihistamines, and EGFR-kinase inhibitors, processes for preparing them and their use in the treatment of respiratory diseases.
Claims28
A pharmaceutical composition comprising:
- (a) an anticholinergic which is a tiotropium salt;
- and (b) an antihistamine which is epinastine;
- optionally together with a pharmaceutically acceptable excipient, the anticholinergic and the antihistamine optionally in the form of their enantiomers, mixtures of their enantiomers, their racemates, or their hydrates.
A pharmaceutical composition consisting essentially of:
- (a) an anticholinergic which is a tiotropium salt;
- and (b) an antihistamine which is epinastine;
- wherein the pharmaceutical composition is in the form of an inhalable powder.
A pharmaceutical composition consisting essentially of:
- (a) an anticholinergic which is a tiotropium salt;
- (b) an antihistamine which is epinastine;
- (c) a solvent;
- (d) benzalkonium chloride;
- and (e) sodium edetate.
A pharmaceutical composition consisting essentially of:
- (a) an anticholinergic which is a tiotropium salt;
- (b) an antihistamine which is epinastine;
- (c) a solvent;
- and (d) benzalkonium chloride.
A kit comprising one or more unit dosage containers containing a pharmaceutical composition, each unit dosage container containing a pharmaceutical composition comprising:
- (a) an anticholinergic which is a tiotropium salt;
- and (b) an antihistamine which is epinastine, each optionally together with a pharmaceutically acceptable excipient, the anticholinergic and the antihistamine optionally in the form of their enantiomers, mixtures of their enantiomers, their racemates, or their hydrates.
A kit comprising:
- (a) a first container containing a first pharmaceutical formulation comprising an anticholinergic which is a tiotropium salt;
- and (b) a second container containing a second pharmaceutical formulation comprising an antihistamine which is epinastine, each container each optionally further containing a pharmaceutically acceptable excipient, the anticholinergic and the antihistamine optionally in the form of their enantiomers, mixtures of their enantiomers, their racemates, or their hydrates.
Dependencies are inferred from the claim text.