Nucleic acid encoding apolipoprotein E-I3
AssigneeThe J. David Gladstone Institutes
InventorsYadong Huang, Qin Xu
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Abstract
The present invention provides nucleic acids comprising a nucleotide sequence encoding an apolipoprotein E (apoE) splice variant, e.g., an unprocessed apoE, that retains intron 3; and vectors and host cells comprising same. The present invention further provides screening methods to identify agents that inhibit cleavage of intron-3 from the apoE splice variant. The present invention further provides methods of treating apoE-related neurological disorders, involving administering an agent that inhibits removal of intron-3 from a precursor apoE mRNA.
Claims12
An isolated nucleic acid comprising a nucleotide sequence having at least 95% nucleotide sequence identity to the nucleotide sequence set forth in SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.