Ferric organic compounds, uses thereof and methods of making same
AssigneePanion & BF Biotech Inc.
InventorsDavid W. K. Kwok, Nikolay Mintchev Stoynov
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Abstract
The present invention discloses a novel form of ferric organic compounds, including a form of ferric citrate, which are soluble over a wider range of pH, and which have a large active surface area. The ferric organic compounds of the present invention can be delivered effectively by oral route with better delivery to treat patients suffering from hyperphosphatemia, metabolic acidosis and other disorders responsive to ferric organic compound therapy.
Claims15
A solid form of ferric citrate having a formula of C6H5O7Fe and an intrinsic dissolution rate between 1.9 and 4.0 mg/cm2/min, as determined by the USP intrinsic dissolution assay in water, wherein the solid form of ferric citrate is synthesized by a method comprising:
- (a) adding an alkaline metal hydroxide solution to a ferric chloride solution;
- (b) isolating a ferric hydroxide precipitate;
- (c) forming a suspension of the ferric hydroxide precipitate in water;
- (d) adding citric acid to the suspension and forming a ferric-citric acid solution by heating said suspension with said citric acid;
- and
- (e) precipitating the solid form of ferric citrate by mixing the ferric-citric acid solution with an organic solvent.
Dependencies are inferred from the claim text.