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US 7,767,842 B2Granted
Class of γδ T cells activators and use thereof
AssigneeInnate Pharma
InventorsChristian Belmant, Patrice Nury
Life of this patent
Estimating the term…
Abstract
The present invention relates to a new class of compounds having γδ T cells activating properties of Formula (I), a composition comprising these compounds and methods for regulating an immune response in a subject comprising the step of administering these compounds.
Claims14
A compound selected from:
- in which R3, R4, and R5, identical or different, are a hydrogen or (C1-C3)alkyl group, W is —CH— or —N—, R6 is a (C2-C3)acyl, an aldehyde, a (C1-C3)alcohol, or a (C2-C3)ester, Cat+ represents H+, Na+, NH4+, K+, Li+, (CH3CH2)3NH+, lysine or any other suitable pharmaceutically acceptable cation, B is O or NH, m is an integer from 1 to 3, and Y is O−Cat+, a nucleoside, or a radical -A-R, wherein A is O, NH, CHF, CF2 or CH2, and R is selected from the group consisting of:
- wherein n is an integer from 2 to 20, R1 is a (C1-C3)alkyl group, and R2 is a halogenated (C1-C3)alkyl, a (C1-C3)alkoxy-(C1-C3)alkyl, a halogenated (C2-C3)acyl or a (C1-C3)alkoxy-(C2-C3)acyl;
- wherein n is an integer from 2 to 20, and R1 is a methyl or ethyl group;
- and
- wherein R3, R4, and R5, identical or different, are a hydrogen or (C1-C3)alkyl group, W is —CH— or —N—, and R6 is a (C2-C3)acyl, an aldehyde, a (C1-C3)alcohol, or a (C2-C3)ester;
- in which R3, R4, and R5, identical or different, are a hydrogen or (C1-C3)alkyl group, W is —CH— or —N—, R6 is a (C2-C3)acyl, an aldehyde, a (C1-C3)alcohol, or a (C2-C3)ester, Cat+ represents H+, Na+, NH4+, K+, Li+, (CH3CH2)3NH+, lysine or any other suitable pharmaceutically acceptable cation, B is O or NH, m is an integer from 1 to 3, and Y is O−Cat+, a nucleoside, or a radical -A-R, wherein A is O, NH, CHF, CF2 or CH2, and R is selected from the group consisting of:
- wherein n is an integer from 2 to 20, R1 is a (C1-C3)alkyl group, and R2 is a halogenated (C1-C3)alkyl, a (C1-C3)alkoxy-(C1-C3)alkyl, a halogenated (C2-C3)acyl or a (C1-C3)alkoxy-(C2-C3)acyl;
- wherein n is an integer from 2 to 20, and R1 is a methyl or ethyl group;
- and
- wherein R3, R4, and R5, identical or different, are a hydrogen or (C1-C3)alkyl group, W is —CH— or —N—, and R6 is a (C2-C3)acyl, an aldehyde, a (C1-C3)alcohol, or a (C2-C3)ester;
- or
8 more elements
A composition comprising a carrier and a compound selected from:
- in which R3, R4, and R5, identical or different, are a hydrogen or (C1-C3)alkyl group, W is —CH— or —N—, R6 is a (C2-C3)acyl, an aldehyde, a (C1-C3)alcohol, or a (C2-C3)ester, Cat+ represents H+, Na+, NH4+, K+, Li+, (CH3CH2)3NH+, lysine or any other suitable pharmaceutically acceptable cation, B is O or NH, m is an integer from 1 to 3, and Y is O−Cat+, a nucleoside, or a radical -A-R, wherein A is O, NH, CHF, CF2 or CH2, and R is selected from the group consisting of:
- wherein n is an integer from 2 to 20, R1 is a (C1-C3)alkyl group, and R2 is a halogenated (C1-C3)alkyl, a (C1-C3)alkoxy-(C1-C3)alkyl, a halogenated (C2-C3)acyl or a (C1-C3)alkoxy-(C2-C3)acyl;
- wherein n is an integer from 2 to 20, and R1 is a methyl or ethyl group;
- and
- wherein R3, R4, and R5, identical or different, are a hydrogen or (C1-C3)alkyl group, W is —CH— or —N—, and R6 is a (C2-C3)acyl, an aldehyde, a (C1-C3)alcohol, or a (C2-C3)ester;
- in which R3, R4, and R5, identical or different, are a hydrogen or (C1-C3)alkyl group, W is —CH— or —N—, R6 is a (C2-C3)acyl, an aldehyde, a (C1-C3)alcohol, or a (C2-C3)ester, Cat+ represents H+, Na+, NH4+, K+, (CH3CH2)3NH+, lysine or any other suitable pharmaceutically acceptable cation, B is O or NH, m is an integer from 1 to 3, and Y is O−Cat+, a nucleoside, or a radical -A-R, wherein A is O, NH, CHF, CF2 or CH2, and R is selected from the group consisting of:
- wherein n is an integer from 2 to 20, R1 is a (C1-C3)alkyl group, and R2 is a halogenated (C1-C3)alkyl, a (C1-C3)alkoxy-(C1-C3)alkyl, a halogenated (C2-C3)acyl or a (C1-C3)alkoxy-(C2-C3)acyl;
- wherein n is an integer from 2 to 20, and R1 is a methyl or ethyl group;
- and
- wherein R3, R4, and R5, identical or different, are a hydrogen or (C1-C3)alkyl group, W is —CH— or —N—, and R6 is a (C2-C3)acyl, an aldehyde, a (C1-C3)alcohol, or a (C2-C3)ester;
- or
8 more elements
Dependencies are inferred from the claim text.