# US 7,767,658 B2 · Vaccine composition

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- Number: US 7,767,658 B2
- Document ID: US7767658B2
- Status: Granted
- Kind: B2
- Application number: 11/971,751
- Filed: 2008-01-09
- Published: 2008-06-05
- Granted: 2010-08-03
- Earliest claimed: 2003-11-17
- Assignees: Aventis Pasteur Limited
- Inventors: Jean Haensler
- Web page: https://patentgrep.com/patent/US7767658B2

## CPC

- A61K 39/21: Retroviridae, e.g. equine infectious anemia virus
- A61K 39/12: Viral antigens
- A61K 39/215: Coronaviridae, e.g. avian infectious bronchitis virus
- A61K 39/245: Herpetoviridae, e.g. herpes simplex virus
- A61K 39/39: characterised by the immunostimulating additives, e.g. chemical adjuvants
- A61P 37/00: Drugs for immunological or allergic disorders
- A61P 37/04: Immunostimulants
- A61K 2039/545: {characterised by the dose, timing or administration schedule}
- A61K 2039/55555: {Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers}
- A61K 2039/55566: {Emulsions, e.g. Freund's adjuvant, MF59}
- A61K 2039/57: {characterised by the type of response, e.g. Th1, Th2}
- C12N 2710/16134: Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- C12N 2740/16334: Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

The present invention relates to a pharmaceutical composition comprising at least one vaccine antigen, which also comprises at least one phosphoric ester derivative of phosphatidylcholine having the structure: in which: R1 is a lower alkyl, R2 and R3 are identical or different, and can each represent linear hydrocarbon-based chains having from 13 to 21 carbon atoms.

## Claims

### Claim 1

A method for immunizing a mammal, the method comprising administering to said mammal at least one vaccine antigen and a phosphoric ester derivative of phosphatidylcholine having the structure:
wherein,
R1 is a lower alkyl,
R2 and R3 are identical or different, and each is a linear hydrocarbon-based chain having from 13 to 21 carbon atoms.

### Claim 2 (depends on 1)

The method according to claim 1 wherein R1 is ethyl.

### Claim 3 (depends on 1)

The method according to claim 1 wherein R2 and R3 are chosen from the radicals originating from myristic acid, palmitic acid, stearic acid or oleic acid.

### Claim 4 (depends on 1)

The method according to claim 1 wherein R2 and R3 are both identical and represent the oleic acid radical.

### Claim 5 (depends on 2)

The method according to claim 2 wherein R2 and R3 are chosen from the radicals originating from myristic acid, palmitic acid, stearic acid or oleic acid.

### Claim 6 (depends on 5)

The method according to claim 5 wherein R2 and R3 are both identical and represent the oleic acid radical.