Method for monitoring the stereoselectivity and relative rate of organic chemical reactions
AssigneeNUtech Ventures
InventorsDavid B. Berkowitz, Sangeeta Dey, Kannan R. Karukurichi, Weijun Shen
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Abstract
A method for monitoring the stereoselectivity of at least one organic chemical reaction and the relative rate of at least one organic chemical reaction, wherein the reaction produces a product that can exist as at least two stereoisomers, is provided herein. Also disclosed are methods for identifying and preparing catalysts for the above reactions.
Claims29
A method for monitoring the stereoselectivity of at least one organic chemical reaction and the relative rate of at least one organic chemical reaction, wherein the reaction produces a product that can exist as at least two stereoisomers, the process comprising:
- providing a first reaction zone containing (1) an organic phase comprising the reaction mixture for producing said product and (2) an aqueous phase adjacent to, but substantially immiscible with said organic phase, said aqueous phase containing at least one first sensing agent that preferentially acts on a first stereoisomer in said product to produce a monitorable change, said product being diffusible into said aqueous phase (2);
- providing a second reaction zone containing (A) an organic phase also comprising the reaction mixture for producing said product and (B) an aqueous phase adjacent to, but substantially immiscible with said organic phase, said aqueous phase containing at least one second sensing agent that is different from said first sensing agent and
- [i] preferentially acts on the first stereoisomer in the product, but with a different stereoselectivity for the stereoisomers formed in the product than the first sensing agent to produce a monitorable change or
- [ii] acts at equal rates on both formed stereoisomers of the product to produce a monitorable change or
- [iii] preferentially acts on a second stereoisomer in the product to produce a monitorable change,
- said product being diffusible into said aqueous phase (B),
- conducting said reactions in said organic phases (1) and (A) to produce said product,
- allowing said product to diffuse into said aqueous phases (2) and (B) and react with said first and second sensing agents,
- monitoring the changes caused by said reactions with said first and second sensing agents and
- correlating said changes to determine the relative rate and stereoselectivity of said organic chemical reaction in said organic phases (1) and (A).
Dependencies are inferred from the claim text.