Systems and methods for intra-oral diagnosis

A method for intra-oral diagnosis and treatment, comprising:

• removeably placing a dental appliance on a patient's teeth, the appliance including:
• a number of cavities that conform to the patient's teeth, but are slightly out of alignment with a current configuration of the patient's teeth;
• one or more sensors attached to the dental appliance;
• a processor located on the dental appliance;
• one or more delivery nozzles that project from the dental appliance and are shaped to conform with with a respective periodontal pocket of the patient;
• and
• one or more reservoirs in fluid communication with the one or more delivery nozzles;
• sampling an intra-oral substance with the sensor;
• detecting one or more medical conditions with the processor based on output received from the sensor regarding the intra-oral substance;
• providing treatment in a closed-feedback loop, including:
• activating the one or more delivery nozzles that project from the appliance and insert into the respective periodontal pocket of the patient;
• and
• delivering drugs or therapeutic agents from one or more reservoirs through the delivery nozzles to the patient.