Replikins and methods of identifying replikin-containing sequences
OwnerSamuel Bogoch, Elenore S. Bogochinventors
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Abstract
The present invention provides methods for identifying a class of peptides referred to as replikins and methods of using replikins to stimulate the immune system of a subject. The method of identifying replikin peptides is based on identifying amino acid sequences comprising 7 to about 50 amino acids that contain (1) at least one lysine residue located six to ten residues from a second lysine residue; (2) at least one histidine residue; and (3) at least 6% lysine residues.
Claims40
An isolated or synthesized viral Replikin peptide consisting of 7 to 50 amino acids and comprising:
- (1) a first lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and
- (3) at least 6% lysine residues,
- wherein said peptide comprises a sequence selected from the group consisting of SEQ ID NO:
- 47, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 48, SEQ ID NO:
- 49, SEQ ID NO:
- 51, SEQ ID NO:
- 54, SEQ ID NO:
- 55, SEQ ID NO:
- 56, SEQ ID NO:
- 57, SEQ ID NO:
- 58, SEQ ID NO:
- 60, SEQ ID NO:
- 61, SEQ ID NO:
- 62, SEQ ID NO:
- 63, SEQ ID NO:
- 64, SEQ ID NO:
- 18, SEQ ID NO:
- 73, and SEQ ID NO:
- 6.
An isolated or synthesized peptide consisting of the sequence selected from the group consisting of SEQ ID NO:
- 47, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 48, SEQ ID NO:
- 49, SEQ ID NO:
- 51, SEQ ID NO:
- 54, SEQ ID NO:
- 55, SEQ ID NO:
- 56, SEQ ID NO:
- 57, SEQ ID NO:
- 58, SEQ ID NO:
- 60, SEQ ID NO:
- 61, SEQ ID NO:
- 62, SEQ ID NO:
- 63, SEQ ID NO:
- 64, SEQ ID NO:
- 18, SEQ ID NO:
- 73, and SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.