Pharmaceutical compositions comprising cannabidiol derivatives

A process for the preparation of a compound-having general Formula I,

• wherein R′ is CH2OH and R″ is selected from the group consisting of:
• a. a straight or branched alkyl of 5 to 12 carbon atoms;
• b. a group —O—R′″, where R′″ is a straight or branched alkyl of 5 to 9 carbon atoms, or a straight or branched alkyl substituted at the terminal carbon atom by a phenyl group;
• and
• c. a group —(CH2)n-O-alkyl, where n is an integer from 1 to 7 and the alkyl group contains 1 to 5 carbon atoms,
• the process comprising:
• (a) blocking the phenolic groups of the following compound
• wherein R″ is selected from the group above;
• (b) selective epoxidation of the ring double bond of the compound obtained in step (a);
• (c) selective opening of the epoxide ring of the compound obtained in step (b) to form the corresponding allylic alcohol;
• (d) performing an allylic rearrangement of the compound obtained in step (c) to obtain the following compound
• (e) demethoxylating the compound obtained in step (d) to thereby prepare the compound of general formula I.