Bipolar trans carotenoid salts and their uses
AssigneeDiffusion Pharmaceuticals LLC
InventorsJohn L. Gainer, Raymond C. Grabiak
Life of this patent
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Abstract
The invention relates to trans carotenoid salt compounds, methods for making them, methods for solubilizing them and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.
Claims11
A method of solubilizing a BTCS having the structure
- YZ-TCRO-ZY
- where:
- Y=a cation
- Z=a polar group which is associated with the cation, and
- TCRO=trans carotenoid skeleton
- comprising the steps of:
- a) preparing a dilute solution of sodium carbonate or sodium bicarbonate,
- b) adding said dilute solution to deionized water to raise the pH to 7 or above,
- c) adding a BTCS to the solution of step b).
A method of solubilizing a BTCS having the structure
- YZ-TCRO-ZY
- where:
- Y=a cation
- Z=a polar group which is associated with the cation, and
- TCRO=trans carotenoid skeleton
- comprising the steps of:
- a) adding a BTCS to a saline solution,
- b) removing undissolved material.
A method of solubilizing a BTCS having the structure
- YZ-TCRO-ZY
- where:
- Y=a cation
- Z=a polar group which is associated with the cation, and,
- TCRO=trans carotenoid skeleton
- comprising the steps of:
- a) adding a base to water to make a basic solution,
- b) adding a BTCS to said solution.
A method of solubilizing a BTCS having the structure
- YZ-TCRO-ZY
- where:
- Y=a cation
- Z=a polar group which is associated with the cation, and
- TCRO=trans carotenoid skeleton
- comprising the steps of:
- a) preparing deionized water,
- b) adding a BTCS to the solution of step a).
A method of treating complications of diabetes comprising administering to a mammal in need of treatment a therapeutically effective amount of a compound having the formula
- YZ-TCRO-ZY
- where:
- Y=a cation
- Z=a polar group which is associated with the cation, and
- TCRO=trans carotenoid skeleton.
A method of treating Alzheimer's disease comprising administering to a mammal in need of treatment a therapeutically effective amount of a compound having the formula
- YZ-TCRO-ZY
- where:
- Y=a cation
- Z=a polar group which is associated with the cation, and
- TCRO=trans carotenoid skeleton.
A method of treating diabetes comprising administering to a mammal in need of treatment a therapeutically effective amount of BTCS wherein absorbency of the highest peak which occurs in the visible wave length range divided by the absorbency of the peak which occurs in the UV wave length range is greater than 7.5, and wherein the BTCS is TSC.
A method of treating Alzheimer's disease comprising administering to a mammal in need of treatment a therapeutically effective amount of BTCS wherein absorbency of the highest peak which occurs in the visible wave length range divided by the absorbency of the peak which occurs in the UV wave length range is greater than 7.5, and wherein the BTCS is TSC.
Dependencies are inferred from the claim text.